Have restrictions other than prior authorization, quantity Typically requires that certain criteria be met prior to Step therapy associated with each prescription. Restriction typically limits the quantity of the drug that will Have quantity limits associated with each prescription. Specific clinical criteria be met prior to the approval of the MostĬommonly, these are "non-preferred" brand drugs.Ĭommonly, these are "non-preferred" brand drugs or specialty This drug is available at a higher level co-pay. MostĬommonly, these are "preferred" (on formulary) brand drugs. This drug is available at a middle level co-pay. This drug is available at the lowest co-pay.
VERSED ANTIDOTE PROFESSIONAL
Always ask your health care professional for complete information about this product and your specific health needs. This information is not individual medical advice and does not substitute for the advice of your health care professional. This information does not assure that this product is safe, effective, or appropriate for you.
VERSED ANTIDOTE HOW TO
IMPORTANT: HOW TO USE THIS INFORMATION: This is a summary and does NOT have all possible information about this product. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product. Properly discard this product when it is expired or no longer needed. STORAGE: Consult your pharmacist.Do not flush medications down the toilet or pour them into a drain unless instructed to do so.
NOTES: No monograph available at this time. Canada residents can call a provincial poison control center. US residents can call their local poison control center at 1-80. Otherwise, call a poison control center right away. OVERDOSE: If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. You may report side effects to Health Canada at 1-86.ĭRUG INTERACTIONS: Consult your pharmacist.Keep a list of all your medications with you, and share the list with your doctor and pharmacist. You may report side effects to FDA at 1-80 or at Canada - Call your doctor for medical advice about side effects. SIDE EFFECTS: Consult your pharmacist.In the US -Call your doctor for medical advice about side effects. Not for diagnosis of benzodiazepine-induced sedation Unmasking of seizures, precipitation of benzodiazepine withdrawal Use caution in patients with panic disorder Use caution in patients with hepatic dysfunction If seizure after flumazenil, recommend valium 20-30 mg, then immediately to barbiturates Resedation occurs frequently in patients who have received a large single dose or cumulative dose of a benzodiazepine administered along with a neuromuscular blocker and multiple anesthetic agents May cause CNS depression and impair ability to perform hazardous tasks Not for reversal of respiratory depression (need to establish an airway, assist ventilation, and continue to observe patient)-monitor for return of respiratory depression/sedation Possible concomitant: Cyclic antidepressant overdoseĬhronic benzodiazepine user patients receiving a benzodiazepine for life-threatening condition (eg, intracranial pressure control, status epilepticus) Cautions Hypersensitivity to flumazenil or benzodiazepines Practitioners should individualize the dosage of flumazenil and be prepared to manage seizures. These are most frequent in patients who have been on benzodiazepines for long-term sedation or in overdose cases where patients are showing signs of serious cyclic antidepressant overdose. The use of flumazenil has been associated with seizures.
Hepatic impairment: Initial dose adjustment not necessary reduce dose or frequency of subsequent doses
Slow infusion of lowest dose required to decrease adverse effects Dosing Modifications Rarely patient may require titration up to total dose 5 mg IF no response after 5 min, sedation unlikely to be secondary to benzodiazepines Dosing Considerations In the event of resedation, may repeat dose at 20-min intervals if needed not to exceed 1 mg (administered as 0.5 mg/min) administered at any one time and no more than 3 mg/hr IF no response after 30 sec, administer 0.3 mg over 30 sec 1 min later IF no response, repeat dose of 0.5 mg IV over 30 sec at 1-min intervals to max cumulative dose of 3 mg/hr IF resedation occurs, may repeat doses at 20-min intervals not to exceed 1 mg/dose or 3 mg/hr Benzodiazepine Overdose IF after 45 sec no response, administer 0.2 mg again over 1 min may repeat at 1 min intervals not to exceed 4 doses (1 mg) Reversal of Conscious Sedation and General Anesthesia Dosage Forms & Strengths injectable solution
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